This will be a topic that I will post on occasionally. As many synthetic chemists have utilized polymeric resins and peptides to attach to core functionality and modify with many of the common reactions, we now see this done with CNTs. Many people are excited and feel that we can utilize this process to better understand drug delivery and potentially targeted cancer therapy. Much of this research doesn’t make it to the traditional medicinal chemistry journals (yet), but are typically discussed in the materials field. A recent account from the 4th International Conference on Nanostructures illustrates how CNTs can be functionalized with some reasonably standard chemistry.

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MWCNT functionalization by MW

Without activatiion the CNT-CO2H, and the 2-amino-4-thiazolinone in DMF were placed in a microwave reactor for 20 minutes. Following cool down and washing, the modified amide in DMF was reacted with phenyl hydrazine under microwave heating for 20 minutes to form the desired fuzed heterocycle. The only thing I didn’t particularly like about the process of not using a temperature to define the microwave program, or at least a description of the temperatures reached. Aside from that, this certainly seems like a good way to generate a library of compounds to study. SEM images of the CNTs are shown below…I am starting to get used to seeing differences in the images….let me know what you think.

SEM MWCNT images

SEM MWCNT images

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