I am always looking for funny ways people apply the latest technology or methodology in the literature. Just do an analysis of the number of papers that come out after the big papers on metathesis, Buchwald-couplings, click chemistry……ok you get it, even I ran around trying some cascade reactions (in my case it was Pummerer derived). Funnier things take place — try and perform a 6-10 step synthesis with only Pd couplings — it’s a fun way to spend a few hours coming up with something. For my literature reference of the week (2011)– I found a convergent 6 step microwave synthesis of a 2-{4-[2-(N-Methyl-2-pyridylamino)ethoxy]phenyl}-5-Substituted 1,3,4-oxadiazole  library….I mean every step included a microwave step. I had to double check. It was a nice process for producing a library of analogs (could be done at a few different places, although this group had a specific left-hand piece) and even concluded with a cycloaddition step at the end to form the oxadiazole.

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Microwave steps abound

There’s nothing much more to say other than…see if you can give me examples where someone has used a specific reaction, reagent or technology to run multiple steps throughout the entire process — it has to be several steps though. Maybe next week I will use microwave synthesis to set up the northern warhead of a complex total synthesis…..hehehe, some of the vernacular that gets picked up makes me think that I will start using cartoons to name starting materials coming together.

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