Wanted to post some interesting reads — always fun to see scientists move from reactions taking 1-2 days down to an hour or minutes. Many times however, when we see this, there is a strong desire to understand it. Hey I can’t hit an 85 mile/hour curve ball either but I am ok not knowing all the details — suffice to say there are more and more publications on the “strangeness” of microwave accelerated reactions — especially those that take place in solution.

Here is a list of a few recent publications that are worth reading:

1. http://cen.acs.org/articles/92/i11/Stimulated-Microwaves.html Org Lett – Ru-mediated ring-closing metathesis of an oligopeptide was sluggish with oil-bath heating—taking hours. But it proceeded rapidly—that is, in two to five minutes—with microwave heating. Paper

2. Early 2014 discussion from FSU researcher, Dudley http://www.chem.fsu.edu/dudley/files/CEN2014

3. JOC 2010: http://pubs.acs.org/doi/abs/10.1021/jo1011703 Challenging Ru-catalyzed ring-closing metathesis transformations leading to eight-membered-ring systems and Ni- or Co-catalyzed [2+2+2] cyclotrimerizations were evaluated at elevated temperatures applying microwave dielectric heating or conventional thermal heating in order to investigate the role of wall effects.

4. Kappe’s microwave effects review late 2012: http://onlinelibrary.wiley.com/doi/10.1002/anie.201204103/abstract

and the Buchwald paper from the previous post….

5. Paper pdf link

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