Totally Microwave

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My last musing went into the use of enzyme catalysis as an effective tool in the microwave toolbox. Although not used enough, there are some focused hotspots for lipases — but a concern that there hasn’t been more development. Ran into a recent publication (Molecules 2013) taking on this approach for synthetically value products in non-aqueous media.

If you know the field you have to accept some of the challenges that go along with the field: Low enzyme activity and that these enzymes are not being used for their natural substrates…..which often means a lot of experimentation — (who is going to screen and categorize for us?).

So this Chinese research team (from several different labs) added microwave to some of the things they learned from their conventional application — APE 1547 (a thermophilic esterase from the archaeon Aeropyrum pernix K1) selective esterification of Ibuprofen– from the baseline temperature…

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