Here is a quick link (pdf available) to a recent publication from Giancarlo Cravotto at the University of Turin. Known for enabling technologies for several fields of application including synthesis utilizing ultrasound, microwave and multiple techniques for extraction of bioactive compounds. In this paper, the group utilized a new microwave design to run multiple reactions simultaneously in a single-reaction chamber. Several key things about the design: 1) the single-reaction chamber (SRC) is a high temperature, high pressure reactor (looks a little like a Parr reactor) 2) 2-3 gas valves for the addition or modification of a reaction with a reactive gas 3) mechanical stirrer or a specialized rack system connected to an overhead stirrer to agitate multiple reactions. One of the highlights is that the reaction vessel is the microwave cavity and that multiple reactions are placed in a pool of microwave absorbing liquid where the temperature is monitored. Following pre-pressurization, microwave energy is applied and the chamber is uniformly heated and all reactions are under the same set of temperature and pressure conditions. Here’s the cool part — follow the physical chemistry….if the entire chamber is pressurized, each reaction in the chamber has a virtually closed cap of pressure (hence the pre-pressurization) and allows the capability of doing different reactions in each vessel (now we can heat non-absorbing solvents such as THF, dioxane and hexanes). The result is that there isn’t any crossover from one reaction to the next. Highlights are solvent choice, catalyst loading/choice for Heck, Suzuki and a Click chemistry example……picture below give you an idea to run with.
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Recent Posts
- Effective use of an inverse demand Diels-Alder: the microwave way November 20, 2014
- Combination of MW and Nanocatalysts with Magnetic Core: Greener Approach to Synthesis November 11, 2014
- Alpha-arylation of 3-benzazepin-2-ones with microwave heating November 10, 2014
- Domino 3 Component Microwave: Mannich, Indole formation, N-Arylation November 7, 2014
- Aristolactams: One-pot Miyaura-Suzuki/Aldol cascade microwave method November 6, 2014
Chemistry Resources
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Labs Utilizing Microwave Strategies
- Albert Stiegman – Florida State University
- Dr. Nicholas Leadbeater – University of Connecticut
- Florida State University – Gregory Dudley
- FMF-Nanolab at the University Freiburg
- Idaho State University – Joshua Pak
- O. Kappe – University of Graz
- UCLM – Microwave and Sustainable Organic Chemistry
- University of Kansas – Paul Hanson
- University of Turin – Giancarlo Cravotto
- York University – Michael Organ
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[…] different (and I have detailed a new way to think of MW reactions in a single-reaction chamber SRC)– I want to take full advantage of the solvents used in traditional approaches but utilize […]
[…] felt a little let down at the part of the movie……you have heard me talk about microwave SRC technology — this is where you could screen solvent, base catalyst, amines, ligands all at […]
[…] some differences in reaction time and temp so it took some time to conclude (see my thoughts on SRC screening and this would have taken 30 minutes tops running all of the reactions at 110C for 20 […]